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. 2023 Jun 30;14:3884. doi: 10.1038/s41467-023-39538-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a The number of putative cell type-specific functional regulatory variants and associated genes inferred from Huatuo in each cell type. b Systematical validation of putative cell type-specific regulatory variants using an external scATAC-seq dataset. The heatmap shows z-scores for the enrichment of putative regulatory variants of each investigated HCL cell type (y-axis) in the differential chromatin accessibility of each cell type from an external scATAC-seq dataset (x-axis). The enrichment was evaluated using AUC scores, reflecting the extent of agreement between the inferred cell type-specific regulatory variants and the observed cell type-specific regulatory regions. The color-coding of labels on both the x-axis and y-axis indicates the cell lineage assignment of investigated cell types.