Table 2.
Mutations detected, frequency and response to TKI therapy.
| Name of mutation | Number detected | Imatinib | Nilotinib | Dasatinib |
|---|---|---|---|---|
| G250E | 11 | |||
| T315I | 6 | |||
| F359I | 5 | |||
| F359V | 4 | |||
| A399T | 4 | |||
| M244V | 4 | |||
| E255K | 4 | |||
| H396R | 2 | |||
| E255V | 2 | |||
| F317L | 2 | |||
| D363_R386del | 2 | |||
| V260A | 1 | |||
| V260G | 1 | |||
| V260M | 1 | |||
| K219R | 1 | |||
| A412S | 1 | |||
| H396Y | 1 | |||
| E275K | 1 | |||
| G259D | 1 | |||
| Y253F | 1 | |||
| Y253H | 1 | |||
| I242V | 1 | |||
| I293N | 1 | |||
| E282V | 1 | |||
| V280M | 1 | |||
| E279K | 1 | |||
| V339M | 1 | |||
| G254R | 1 | |||
| Y312C | 1 | |||
| R307N | 1 | |||
| V299L | 1 | |||
| F311I | 1 | |||
| C330R | 1 | |||
| L248V | 1 | |||
| V225F | 1 | |||
| P367Q | 1 | |||
| V304RfsTer14 | 1 | |||
| L248_L247del | 1 | |||
| N331D | 1 | |||
| Q300* | 1 |
Note: Full/partial resistance 
, Full/partial sensitivity 
, Unknown 
.