. 2023 Jun 30;6(7):e1376. doi: 10.1002/hsr2.1376

Table 4.

Mutations with known effect on TKI, choice of TKI, and response observed.

Patient number	Name of mutation	Reported effect on TKI	Choice of TKI	Patient response
8	F359I	S – D, R – N, PR ‐ I	Dasatinib	Undetermined
10	F359I	S – D, R – N, PR ‐ I	Dasatinib	Poor^a
16	G250E	R – I and N, S ‐ D	Nilotinib	Poor
40	G250E	R – I and N, S ‐ D	Nilotinib	Poor
	F359V	S – D, R – I and N	Dasatinib	Poor^a
43	H396R	S – D and N, PR ‐ I	Nilotinib	Good
74	F359I	S – D, R – N, PR ‐ I	Dasatinib	Good
82	M244V	S – D and N, PR ‐ I	Nilotinib	Undetermined
85	T315I	R – D, N, I	Nilotinib	Good^a
86	F359V	S – D, R – I and N	Dasatinib	Good
87	G250E	R – I and N, S ‐ D	Dasatinib	Poor^a
	Y253F	S – D, R – I, PR ‐ N	Dasatinib	Poor^a
	F359V	S – D, R – I and N	Dasatinib	Poor^a
88	E255K	S – D, R – I, PR ‐ N	Dasatinib	Good
90	M244V	S – D and N, PR ‐ I	Dasatinib	Poor^a
	F359I	S – D, R – N, PR ‐ I	Dasatinib	Poor^a
92	T315I	R – D, N, I	Nilotinib	Undetermined
95	E255K	S – D, R – I, PR ‐ N	Dasatinib	Undetermined
97	F359I	S – D, R – N, PR ‐ I	Dasatinib	Undetermined
98	E279K	S – D and N, PR ‐ I	Nilotinib	Undetermined
100	E255K	S – D, R – I, PR ‐ N	Nilotinib	Poor
			Dasatinib	Undetermined
101	F359V	S – D, R – I and N	Dasatinib	Poor^a
104	G250E	R – I and N, S ‐ D	Nilotinib	Undetermined
105	G250E	R – I and N, S ‐ D	Nilotinib	Poor
106	Not documented	S – D and N, PR ‐ I	Nilotinib	Poor
	T315I	R – D, N, I	Dasatinib	Poor
107	H396R	S – D and N, PR ‐ I	Dasatinib	Undetermined
124	M244V	S – D and N, PR ‐ I	Imatinib	Undetermined
125	T315I	R – D, N, I	Hydroxyurea	Undetermined
136	E255V	R – I, PR – D and N	Nilotinib	Poor
137	G250E	R – I and N, S ‐ D	Nilotinib	Undetermined
140	G250E	R – I and N, S ‐ D	Nilotinib	Poor
	T315I	R – D, N, I	Nilotinib	Poor
143	G250E	R – I and N, S ‐ D	Dasatinib	Poor^a
			Nilotinib	Undetermined
	V299L	S – I and N, PR ‐ D	Nilotinib	Undetermined
145	T315I	R – D, N, I	Nilotinib	Poor
154	F311I	R – I and D, PR ‐ N	Nilotinib	Undetermined
159	Not documented	S – D and N, PR ‐ I	Dasatinib	Good
195	Y253H	S – D, R – I, PR ‐ N	Dasatinib	Undetermined
199	G250E	R – I and N, S ‐ D	Nilotinib	Poor
200	E225K	R – I and N, PR ‐ D	Dasatinib	Poor
201	F317L	S – N, PR – I and D	Nilotinib	Poor^a
203	M244V	S – N and D, PR ‐ I	Imatinib	Undetermined
	F317L	S – N, PR – I and D	Imatinib	Undetermined
205	G250E	R – I and N, S ‐ D	Dasatinib	Poor^a
	E225V	S – D, R – I and N	Dasatinib	Poor^a
206	G250E	R – I and N, S ‐ D	Imatinib	Undetermined

Abbreviation: D, Dasatinib; I, Imatinib; N, Nilotinib; PR, partial resistance; R, resistant; S, sensitive; TKI, tyrosine kinase inhibitor.

^{^a}

Discordant response to TKI.