Table 2.

Summary table of the relationship between (altered) endoglin expression, BMP-9 signaling, TGF-β signaling, SCC cell migration, and SCC cell proliferation.

Type	Cell line	Endoglin expression	BMP-9 signaling	TGF-β signaling	Cell migration	Cell proliferation
ESCC	TE01	High	ENG KO ↔	ENG KO ↔	ENG KO ↔	ENG KO ↔
ESCC	TE10	Low	ENG OE ↓	ENG OE ↔	ENG OE ↔	ENG OE ↓
ESCC	TE11	Low	ENG OE ↓	ENG OE ↔	ENG OE ↔	ENG OE ↔
VSCC	VC415-C	Low	TRC105 ↓	TRC105 ↔	ND	ND
VSCC	VC415-S	High	TRC105 ↓	TRC105 ↔	ENG KD ↔	ENG KD ↔
HNSCC	OSC-19	Moderate	TRC105 ↔	ND	TRC105 ↔	ND
HNSCC	FaDu	High	TRC105 ↔	ND	TRC105 ↔	ND

ENG, endoglin; KO, knockout; OE, overexpression; TRC015, endoglin neutralizing antibody; KD, knockdown; ND, not determined; ↔ = no effect, ↓ = decrease.