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. 2023 Jun 9;4(6):101078. doi: 10.1016/j.xcrm.2023.101078

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© 2023 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Subsets of stromal cells identified in this study

(A) UMAP view of ECs, colored by cell subtypes.

(B) Heatmap showing the mean expression of canonical marker genes in different endothelial cell subtypes.

(C) The number and proportion of major endothelial cell subsets in each tissue type.

(D and E) Differences in pathway activities scored per cell by GSVA between tumor and normal ECs (D) and between tumor ECs in smokers and never-smokers (E).

(F) UMAP view of fibroblast cells, colored by cell subtypes.

(G) Heatmap showing the mean expression of canonical marker genes in different fibroblast cell subtypes.

(H) The number and proportion of major fibroblast cell subsets in each tissue type.

(I and J) Differences in pathway activities scored per cell by GSVA between tumor and normal fibroblast cells (I) and between tumor fibroblast cells in smokers and never-smokers (J).