Table 1.

Characteristics of cohort studies reporting postacute health outcomes in children with SARS-CoV-2 infection

	Total N (%)	Controlled n (%)	Uncontrolled n (%)
Total	21 (100)	6 (28.6)	15 (71.4)
Region
Europe	12 (57.1)	5 (83.3)	7 (46.7)
Asia*	6 (28.6)	0 (0)	6 (40)
North America	2 (9.5)	1 (16.7)	1 (6.7)
Oceania	1 (4.8)	0 (0)	1 (6.7)
Population
Hospitalised only	12 (57.1)	1 (16.7)	11 (73.3)
Hospitalised and outpatient	4 (19.0)	1 (16.7)	3 (20)
General population	4 (19.0)	4 (66.7)	0 (0)
Emergency department only	1 (4.8)	0 (0)	1 (6.7)
Sample size
<100	12 (57.1)	1 (16.7)	11 (73.3)
100–500	4 (19.0)	1 (16.7)	3 (20.0)
501–1000	2 (9.5)	1 (16.7)	1 (6.7)
>1000	3 (14.3)	3 (50.0)	–
Definition of exposure (SARS-CoV-2 infection)
Using RT-PCR only	11 (52.4)	1 (16.7)	10 (66.7)
Using RT-PCR or serology	5 (23.8)	2 (33.3)	3 (20.0)
Using RT-PCR, antigen or serology	2 (9.5)	1 (16.7)	1 (6.7)
Unclear†	2 (9.5)	1 (16.7)	1 (6.7)
Using serology only	1 (4.8)	1 (16.7)	0 (0)
Definition of no-exposure (control group)
No diagnosis or symptoms	–	3 (50.0)	–
Using serology	–	2 (33.3)	–
Using RT-PCR	–	1 (16.7)	–
Study registration
Mentioned	2 (9.5)	2 (33.3)	0 (0)
Not mentioned	19 (90.5)	4 (66.7)	15 (100)
Study protocol
Mentioned	2 (9.5)	2 (33.3)	0 (0)
Not mentioned	19 (90.5)	4 (66.7)	15 (100)
Ethical approval
Yes	19 (90.5)	6 (100)	13 (86.7)
No full review†	1 (4.8)	0 (0)	1 (6.7)
Unclear†	1 (4.8)	0 (0)	1 (6.7)

*Including Russia.

†Two studies did not provide information on the methods used^{26 42} As the data analysis was retrospective and no additional data were collected beyond those required for standard medical care, a full ethics review under the terms of the Governance Arrangements of Research Ethics Committees in the UK was not required.

‡One study did not report on ethical approval.³⁴

No., number.