Table 3.
Associations of cancer patients with incident cardiovascular events compared with propensity matched non-cancer controls
| Breast | Lung | Prostate | Colorectal | Uterus | Haematological | |
| Incident disease | ||||||
| IHD | 1.05 (0.93, 1.19) | 1.03 (0.68, 1.57) | 0.92 (0.79, 1.07) | 1.14 (0.94, 1.38) | 1.03 (0.74, 1.42) | 1.92 (1.57, 2.34) |
| 0.428 | 0.899 | 0.297 | 0.181 | 0.868 | 2.02×10−10 | |
| NICM | 1.80 (1.27, 2.56) | – | 1.16 (0.73, 1.86) | 1.25 (0.73, 2.14) | 3.49 (0.72, 16.78) | 2.51 (1.54, 4.10) |
| 0.0008 | – | 0.543 | 0.416 | 0.121 | 0.002 | |
| Heart failure | 1.34 (1.14, 1.57) | 1.92 (1.07, 3.46) | 1.04 (0.85, 1.26) | 0.77 (0.60, 0.99) | 1.38 (0.86, 2.18) | 3.56 (2.69, 4.66) |
| 0.0004 | 0.029 | 0.72 | 0.044 | 0.181 | 1.19×10−19 | |
| AF/flutter | 1.11 (0.98, 1.25) | 1.39 (0.84, 2.32) | 1.00 (0.86, 1.15) | 1.26 (1.04, 1.52) | 1.00 (0.71, 1.42) | 1.97 (1.60, 3.22) |
| 0.114 | 0.206 | 0.969 | 0.02 | 0.996 | 4.43×10−6 | |
| Stroke | 1.13 (0.91, 1.38) | 1.23 (0.58, 2.61) | 1.17 (0.92. 1.49) | 1.12 (0.82, 1.52) | 1.15 (0.68, 1.95) | 2.27 (1.60, 2.44) |
| 0.259 | 0.575 | 0.194 | 0.48 | 0.59 | 2.62×10−10 | |
| Pericarditis | 2.03 (1.36, 3.00) | 12.18 (1.57, 94.63) | 1.16 (0.68, 2.01) | 1.36 (0.68, 2.72) | 3.49 (0.73, 16.95) | 2.94 (1.67, 5.21) |
| 0.0004 | 0.017 | 0.585 | 0.385 | 0.119 | 0.0002 | |
| VTE | 1.45 (1.21, 1.73) | 1.14 (0.53, 2.46) | 1.70 (1.30, 2.23) | 1.21 (0.87, 1.67) | 1.70 (0.91, 3.19) | 2.69 (1.86, 3.94) |
| 6.61×10-5 | 0.736 | 0.0001 | 0.2639 | 0.095 | 2.47×10−7 | |
| Mortality outcomes | ||||||
| All-cause | 2.48 (2.25, 2.72) | 5.00 (3.63, 6.89) | 1.65 (1.46, 1.86) | 2.08 (1.79, 2.41) | 2.41 (1.73, 3.32) | 4.14 (3.49, 4.90) |
| 3.65×10–80 | 7.25×10-21 | 2.40×10–16 | 1.30×10–21 | 3.06×10-7 | 3.10×10−59 | |
| Any CVD | 0.97 (0.70, 1.34) | 2.46 (1.00, 5.99) | 0.87 (0.65, 1.17) | 1.20 (0.80, 1.79) | 1.20 (0.56, 2.59) | 1.48 (0.94, 2.32) |
| 0.871 | 0.05 | 0.371 | 0.374 | 0.64 | 0.087 | |
| IHD | 0.63 (0.38, 1.05) | 1.99 (0.79, 5.05) | 0.87 (0.60, 1.26) | 1.06 (0.65, 1.72) | – | 1.73 (0.91, 3.29) |
| 0.079 | 0.14 | 0.461 | 0.820 | – | 0.090 | |
| Heart failure or NICM | 8.50 (1.95, 36.97) | – | 0.78 (0.29, 2.10) | 5.00 (0.58, 42.95) | – | 1.01 (0.29, 3.49) |
| 0.004 | – | 0.615 | 0.142 | – | 0.991 | |
| Stroke | 0.88 (0.49, 1.57) | – | 0.94 (0.47, 1.86) | 1.22 (0.51, 2.94) | 5.00 (0.58, 42.95) | 1.12 (0.45, 2.77) |
| 0.656 | – | 0.853 | 0.652 | 0.142 | 0.806 | |
| Hypertensive diseases | 8.00 (1.00, 64.07) | – | 1.25 (0.34, 4.66) | – | – | – |
| 0.050 | – | 0.741 | – | – | – |
Results are subdistribution HR (95% CI) and p value associated with cancer exposure (vs no cancer). Blank cells indicate that no analysis was performed due to small number of outcomes (<5) in that category. Comparators are matched on age, sex, ethnicity, deprivation, education, blood pressure, heart rate, body mass index, glycated haemoglobin, random glucose, total cholesterol, high density lipoprotein, low density lipoprotein, triglyceride level, physical activity, smoking, diabetes, hypertension and high cholesterol. The bold cells represent statistically significant associations.
AF, atrial fibrillation; CVD, cardiovascular disease; IHD, ischaemic heart disease; NICM, non-ischaemic cardiomyopathies; VTE, venous thromboembolism.