Table 2.

Shared associations across vasculitides considering MPO and PR3-autoantibody specificity in patients with ANCA-associated vasculitis

Region	Base pair	SNP	Gene	A1	P value	Contributing disease	OR (95% CI)
1p31.3	67 744 601	rs6660226	IL23R/IL12RB2	A	6.78E-11	MPO+_AAV | BD EGPA+KD	1.39 (1.10 to 1.75) | 0.79 (0.74 to 0.85)
1q32.1	206 945 311	rs3024490	IL10*	A	1.49E-08	PR3+_AAV BD	1.24 (1.15 to 1.34)
2q13	111 905 867	rs144569746	BCL2L11*	T	1.11E-08	PR3+_AAV EGPA+EGPA-	1.68 (1.40 to 2.00)
3p21.31	46 208 310	rs2087726	CCR3	G	4.94E-09	PR3+_AAV BD IgAV	0.82 (0.77 to 0.88)
6q23.3	137 514 790	rs4896243	IFNGR1*	C	1.59E-08	MPO+_AAV BD	1.23 (1.15 to 1.32)
8p21.2	27 219 987	rs73223431	PTK2B	T	3.23E-08	MPO+_AAV EGPA+TAK	0.76 (0.69 to 0.84)

Diseases included in the best subset and for which identified associations have not been previously reported are shown in bold.

*New shared associations identified in the meta-analysis considering MPO-positive and PR3-positive AAV as independent phenotypes.

A1, alternative allele used in the logistic regression; AAV, ANCA-associated vasculitis; BD, Behçet’s disease; EGPA+, ANCA-positive eosinophilic granulomatosis with polyangiitis; EGPA-, ANCA-negative eosinophilic granulomatosis with polyangiitis; IgAV, IgA vasculitis; KD, Kawasaki’s disease; TAK, Takayasu arteritis.