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. 2023 Mar 17;82(6):873–880. doi: 10.1136/ard-2022-223468

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Loss of bmp6 causes erosive-like phenotypes in the zebrafish vertebral precursors. (A–C’). Analysis of cartilage (blue) and bone (red) in the vertebral column of 14 days post fertilisation wild-type (WT) and bmp6^+/- zebrafish larvae. (A, A’) WT larvae have a normally segmented and ossified centra (vertebral precursors) and neural (na) and hemal arches (ha), whereas (B, C’) bmp6^+/ ⁻ have multiple defects, including bone erosions (arrow in B and B’), structural defects in the centra (arrowhead in B, C and C’), ectopic cartilage formation (arrow in C’), and disruptions in the neural and hemal arches (asterisks in C’). No defects are observed in the cartilaginous structures of the fins. All images are lateral views with anterior to the left.