Table 2.

Genome wide significant associations with erosive hand osteoarthritis

Variant	Chr:position	EA/NEA	Freq%	Closest gene	VA	P value	OR
rs17013495	4:87 885 460	T/C	59.6	SPP1/MEPE	Intergenic	8.40E-14	1.40 (1.28, 1.53)
rs11243284	6:8 945 086	C/T	28.9		Intergenic	4.20E-11	1.35 (1.23, 1.48)
rs1800801	12:14 885 854	T/C	37.2	MGP	5'UTR	3.60E-13	1.37 (1.26, 1.49)
rs11631127	15:57 977 811	C/G	57.6	ALDH1A2	Intron	7.10E-18	1.46 (1.34, 1.59)

Results are shown from the meta-analysis of the Icelandic, Dutch, Spanish, UK and US sets. Results for individual sample sets are shown in online supplemental table S1. Chr is chromosome, Pos is the position in build GRCh38, EA designate the effect allele (EA) and NEA the other allele (non effect allele). Freq. is the allelic frequency of the effect allele. Gene refers to the nearest gene and VA is variant annotation. 5'UTR is the 5 prime untranslated region. P values are two sided and derived from a likelihood ratio test.