Table 1.

Demographic overview

	HC	NMOSD-NON	NMOSD-ON
Subjects (n)	62	45	28
Eyes (n)	124	90	56
Patients with a disease duration <10 years (n)	.	43	21
Patients with ON as first manifestation (n)	.	.	17
Age (year, mean±SD)	37.7±10.2	39.0±10.4	38.8±12.1
Sex (male, n (%))	20 (32)	2 (4)	3 (11)
Time since ON (year, median (min−max))	.	.	2.8 (0.7–19.5)
Time since onset (year, mean±SD)	.	3.8±4.0	6.5±5.6
pRNFL thickness (µm, mean±SD)	98.5±9.4	98.8±10.8	80.7±24.9
pRNFL IEPD (%, mean±SD)	2.7±2.3	3.7±4.4	28.6±19.9
pRNFL IEAD (µm, mean±SD)	2.7±2.2	3.8±4.5	27.0±19.8
GCIPL thickness (µm, mean±SD)	79.9±5.3	77.6±6.3	66.3±13.2
GCIPL IEPD (%, mean±SD)	1.3±1.1	2.7±3.5	19.0±14.3
GCIPL IEAD (µm, mean±SD)	1.0±0.9	2.1±2.9	14.1±10.9

GCIPL, combined ganglion cell and inner plexiform layer; HC, healthy control; IEAD, intereye absolute difference; IEPD, intereye percentage difference; NMOSD-NON, patients with aquaporin-4-antibody seropositive neuromyelitis optica spectrum disorders and no history of optic neuritis; NMOSD-ON, patients with aquaporin-4-antibody seropositive neuromyelitis optica spectrum disorders and a history of unilateral optic neuritis; ON, optic neuritis; pRNFL, peripapillary retinal nerve fibre layer.