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Molecular dynamics and behaviors of Foxa protein family members. Foxa1 and Foxa2 bind to and open the chromatin of enhancer regions and recruit Hnf4α to similar areas to activate target gene transcription. Foxa3 also binds to and opens the chromatin of enhancer regions. However, Foxa3 promptly translocates from enhancer regions to the vicinity of the transcriptional start sites (TSS), binds to Pol2, and activates target gene transcription by moving on DNA together with Pol2 and Hnf4α.
