Table 1.

Title and topic of ongoing modules that feed the PragMeta database (as of April 2023)

Actively identified and collected for PragMeta:

PragCOVID: Overview of COVID-19 randomized trials self-labeled as pragmatic. It included 37 trials

PragMS: Overview of pragmatic trials in multiple sclerosis [20]. All multiple sclerosis randomized trials likely to be pragmatic have been identified systematically and were assessed using PRECIS-2 for pragmatism. It includes 48 trials

PragQoL: Impact of pragmatism on the assessment of patient-reported outcomes (pain, fatigue, and quality of life) compared with objective clinical outcomes [21]. Cochrane reviews which include a pragmatic labeled trial in meta-analyses assessing pain, fatigue or quality of life and an objective outcome have been systematically identified. It includes 52 trials from 9 clusters

Linkage and import of existing trials not identified and collected for the purpose of PragMeta:

PragEpi: Association of pragmatism with treatment effect estimates [22]. This project collects trials from systematic review and meta-analyses citing and assessing PRECIS-2. It includes 185 trials from 18 clusters

PragSurgery: Collection of PRECIS-2 assessment in surgery trials. This module is the first large actively shared data collection integrated in PragMeta

Except from PragSurgery, all modules have been designed by the PragMeta team