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. 2023 Jun 29;13(6):e065369. doi: 10.1136/bmjopen-2022-065369

Table 3.

Overview of combined treatment and chemoprophylaxis

Screening outcome Treatment offered Rifamycin component
Leprosy Leprosy MDT Monthly rifampicin for 6–12 months
TB TB treatment Daily rifampicin for 6–12 months
RR-TB DR-TB treatment+SDR Single dose rifampicin
Eligible for TPT 3HP or 3RH Weekly rifapentine or daily rifampicin for 3 months
Leprosy HHC SDR-PEP Rifampicin given at baseline and 1 year later
None of the above SDR-MDA Single dose of rifampicin

Screening outcomes are exhaustive but not mutually exclusive. The rifamycin component of each treatment strategy includes sufficient exposure to offer prevention for leprosy, in effect a MDA of leprosy chemoprophylaxis.

DR-TB, drug-resistant tuberculosis; HHC, household contact; 3HP, 3-months of weekly rifapentine and isoniazid; MDA, mass drug administration; MDT, multidrug treatment; NLP, national leprosy program; PCR, polymerase chain reaction; PEP, postexposure prophylaxis; 3RH, 3-months of daily rifampicin and isoniazid; RR-TB, rifampicin-resistant tuberculosis; SDR, single-dose rifampicin; TB, tuberculosis; TPT, tuberculosis preventive treatment.