Table 4.

Risk of medical complications of hypertension according to the MPR level

Complication	Parameter	MPR level
		Excellent	Good	Normal	Bad	Very bad
CAD	Events (N)	2081	811	635	535	405
	IR per 1000 PYR	4	5.1	5.5	5.6	5.5
	HR* (95% CI)	Ref	1.26 (1.16 to 1.37)§	1.35 (1.23 to 1.47)§	1.38 (1.26 to 1.52)§	1.38 (1.24 to 1.53)§
	P value	–	<0.001	<0.001	<0.001	<0.001
Vascular complications	Events (N)	393	154	120	107	89
	IR per 1000 PYR	0.7	1	1	1.1	1.2
	HR* (95% CI)	Ref	1.25 (1.04 to 1.51)†	1.33 (1.08 to 1.63)‡	1.45 (1.17 to 1.79)§	1.59 (1.26 to 2.00)§
	P value	–	0.018	0.007	0.001	<0.001
Cerebrovascular disease	Events (N)	3613	1312	1120	997	775
	IR per 1000 PYR	6.9	8.4	9.8	10.6	10.8
	HR* (95% CI)	Ref	1.18 (1.11 to 1.26) §	1.38 (1.29 to 1.47) §	1.51 (1.41 to 1.62) §	1.54 (1.43 to 1.67) §
	P value	–	<0.001	<0.001	<0.001	<0.001
Heart disease	Events (N)	2585	981	788	659	540
	IR per 1000 PYR	4.9	6.2	6.8	6.9	7.4
	HR* (95% CI)	Ref	1.21 (1.13 to 1.30)§	1.33 (1.23 to 1.44)§	1.36 (1.25 to 1.48)§	1.47 (1.34 to 1.62)§
	P value	–	<0.001	<0.001	<0.001	<0.001
Hypertensive nephropathy	Events (N)	633	278	232	194	147
	IR per 1000 PYR	1.2	1.7	2	2	2
	HR* (95% CI)	Ref	1.39 (1.21 to 1.60)§	1.58 (1.36 to 1.84)§	1.62 (1.38 to 1.90)§	1.62 (1.35 to 1.94)§
	P value	–	<0.001	<0.001	<0.001	<0.001

*Adjusted for sex, age, insurance type, income, number of visits, number of providers, level of hospital and comorbidities

†p<.05

‡p<.01

§p<0.001

CAD, coronary artery disease; MPR, medication possession ratio; N, Number; PYR, person-years at risk.