Table 1.
The baseline characteristics and multivariable linear regression for the MMSE score
| Total n = 633 | Model 1 | Model 2 | |||
|---|---|---|---|---|---|
| β | P value | β | P value | ||
| Age, years, mean ± SD | 62.8 ± 8.9 | −0.125 | 0.001 | −0.113 | 0.015 |
| Female, n (%) | 305 (48.2) | −0.116 | 0.006 | −0.074 | 0.104 |
| Years of education, median (IQR) | 8 (5–12) | 0.484 | <0.001 | 0.481 | <0.001 |
| Hypertension, n (%) | 361 (57.0) | −0.043 | 0.203 | −0.045 | 0.186 |
| Smoking, n (%) | 184 (29.1) | −0.030 | 0.456 | −0.028 | 0.489 |
| DTI-ALPS index, mean ± SD | 1.414 ± 0.193 | 0.101 | 0.004 | 0.108 | 0.003 |
| Cerebral volume, ml, mean ± SD | 1108.9 ± 117.5 | 0.095 | 0.026 | ||
| logWMH volume, ml, mean ± SD | 0.535 ± 0.641 | 0.059 | 0.189 | ||
| Diabetes, n (%) | 107 (16.9) | ||||
| Hyperlipidaemia, n (%) | 118 (18.6) | ||||
DTI-ALPS, diffusion tensor imaging along the perivascular space; MMSE, Mini-Mental State Examination; WMH, white matter hyperintensities; SD, Standard Deviation. Bold indicates p < 0.05.
Model 1: adjusted for age, female, years of education, hypertension and smoking.
Model 2: adjusted for age, female, years of education, hypertension, smoking, cerebral volume and logWMH volume.