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. 2022 Aug 30;149(7):4063–4075. doi: 10.1007/s00432-022-04267-9

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The association between moderate-to-vigorous physical activity at 6 weeks and fatigue at 12 months (total association), divided in a direct path independent of body composition (direct association), and an indirect path via body composition at 6 months (both BMI and handgrip strength—indirect association). Panel A, B, C used different questionnaires or subscales to assess fatigue (EORTC, CIS total, activity-related fatigue, respectively)