Table 3.
Clinico-pathological data of 404 patients with triple negative breast cancer based on BCL11A protein expression
| Protein expression BCL11A | p-value | ||
|---|---|---|---|
| Low | High | ||
| Age at diagnosis (years) | |||
| ≤ 50 | 109 (35.3) | 34 (36.2) | 0.87 |
| > 50 | 200 (64.7) | 60 (63.8) | |
| Site | |||
| Right | 119 (44.9) | 45 (55.6) | 0.11 |
| Left | 145 (54.7) | 35 (43.2) | |
| Bilateral | 1 (0.4) | 1 (1.2) | |
| Histological subtype | |||
| Invasive ductal carcinoma (NST) | 202 (71.4) | 68 (76.4) | 0.09 |
| Apocrine carcinoma | 19 (6.7) | 2 (2.3) | |
| Medullary carcinoma | 17 (6.0) | 12 (13.5) | |
| Invasive lobular carcinoma | 13 (4.6) | 2 (2.3) | |
| Metaplastic + squamous carcinoma | 12 (4.2) | 1 (1.1) | |
| Papillary carcinoma | 5 (1.8) | 0 (0.0) | |
| Other | 15 (5.3) | 4 (4.5) | |
| Tumor size (cm) | |||
| ≤ 20 mm | 106 (47.5) | 32 (45.1) | 0.72 |
| > 20 mm | 117 (52.5) | 39 (54.9) | |
| Histologic grade | |||
| G1 | 4 (1.4) | 3 (3.2) | 0.13 |
| G2 | 45 (15.2) | 8 (8.6) | |
| G3 | 247 (83.5) | 82 (88.2) | |
| Pathologic tumor classification | |||
| pT1 | 102 (35.4) | 36 (39.1) | 0.82 |
| pT2 | 145 (50.4) | 45 (48.9) | |
| pT3 | 23 (8.0) | 5 (5.4) | |
| pT4 | 18 (6.3) | 6 (6.5) | |
| Regional lymph nodes involvement | |||
| pN0 | 156 (54.9) | 54 (60.0) | 0.16 |
| pN1 | 70 (24.7) | 27 (30.0) | |
| pN2 | 32 (11.3) | 5 (5.6) | |
| pN3 | 26 (9.2) | 4 (4.4) | |
| Tumor stage | |||
| I | 67 (26.0) | 17 (23.6) | 0.21 |
| II | 126 (48.8) | 44 (61.1) | |
| III | 59 (22.9) | 11 (15.3) | |
| IV | 6 (2.3) | 0 (0.0) | |
| Necrosis | |||
| Present | 127 (56.7) | 43 (55.1) | 0.81 |
| Absent | 97 (43.3) | 35 (44.9) | |
| Tumor infiltrating lymphocytes | |||
| Present | 151 (69.6) | 46 (61.3) | 0.19 |
| Absent | 66 (30.4) | 29 (38.7) | |
| Lymph vascular invasion | |||
| Present | 91 (42.7) | 20 (27.8) | 0.03 |
| Absent | 122 (57.3) | 52 (72.2) | |
| Ki67 | |||
| ≤ 14% | 21 (7.0) | 3 (3.2) | 0.004 |
| 15–35% | 85 (28.3) | 13 (14.0) | |
| > 35% | 194 (64.7) | 77 (82.8) | |
| Androgen receptor | |||
| < 10% | 128 (72.7) | 50 (87.7) | 0.02 |
| ≥ 10% | 48 (27.3) | 7 (12.3) | |
| Death | 105 (34.5) | 27 (28.7) | 0.30 |