Table 1.
Receptors and related cancers of CXCL family.
| CXCL | Alternative Name | Receptor | Related cancers | Type | Reference |
|---|---|---|---|---|---|
| CXCL1 | Growth-related oncogene (GROα) | CXCR2 | Lung cancer | In vivo | [20] |
| Gastric cancer | In vivo | [27] | |||
| Colorectal Cancer | In vivo and vitro | [31] | |||
| Oral cancer | In vivo and vitro | [63] | |||
| Breast cancer | In vivo | [37] | |||
| Pancreatic cancer | In vivo and vitro | [43] | |||
| Ovarian cancer | In vitro | [53] | |||
| CXCL2 | GRO-β/macrophage inflammatory protein-2 (MIP-2) | CXCR2 | Lung cancer | In vivo | [20] |
| Gastric cancer | In vivo | [27] | |||
| Colorectal cancer | In vivo and vitro | [32] | |||
| Ovarian cancer | In vivo | [54] | |||
| Liver cancer | In vivo and vitro | [48] | |||
| CXCL3 | GRO-γ | CXCR2 | Pancreatic cancer | In vivo and vitro | [43] |
| CXCL4 | Platelet factor 4 (PF-4) | CXCR3 | Gastric cancer | In vivo | [27] |
| Breast cancer | Bioinformatics analysis | [40] | |||
| CXCL5 | Epithelial-derived neutrophil-activating factor-78 (ENA-78) | CXCR1/2 | Lung cancer | Bioinformatics analysis | [22] |
| Gastric cancer | In vivo and vitro | [29] | |||
| Pancreatic cancer | Biomatics analysis | [42] | |||
| Liver cancer | In vivo and vitro | [47] | |||
| Prostate cancer | In vivo and vitro | [59] | |||
| CXCL6 | Granulocyte chemotactic protein-2 (GCP-2) | CXCR1/2 | Lung cancer | In vivo and vitro | [132] |
| Gastric cancer | In vivo | [133] | |||
| Cervical cancer | In vivo and vitro | [134] | |||
| CXCL7 | Neutrophil-activating polypeptide-2 (NAP-2) | CXCR2 | Lung cancer | Bioinformatics analysis | [22] |
| Gastric cancer | In vivo | [27] | |||
| CXCL8 | Interleukin-8 (IL-8) | CXCR1/2 | Lung cancer | In vivo | [20] |
| Gastric cancer | In vivo | [27] | |||
| Colorectal cancer | In vivo | [30] | |||
| Breast cancer | In vivo | [37] | |||
| Pancreatic cancer | In vivo | [44] | |||
| Liver cancer | In vitro | [49] | |||
| CXCL9 | Monokine induced by gamma interferon (MIG) | CXCR3 | Gastric cancer | Bioinformatics analysis | [28] |
| Breast cancer | Bioinformatics analysis | [40] | |||
| CXCL10 | interferon ϒ-inducible protein 10 (IP-10) | CXCR3 | Gastric cancer | Bioinformatics analysis | [28] |
| Liver cancer | Bioinformatics analysis | [51] | |||
| Ovarian cancer | Bioinformatics analysis | [56] | |||
| MelanomaI | In vivo | [62] | |||
| CXCL11 | Human interferon inducible T cell alpha chemokine (I-TAC) | CXCR3 | Gastric cancer | Bioinformatics analysis | [28] |
| Colorectal cancer | In vivo, vitro and bioinformatics analysis | [33] | |||
| CXCL12 | Stromal cell derived factor 1 (SDF-1) | CXCR4/7 | Lung cancer | In vivo | [25] |
| Gastric cancer | In vivo | [27] | |||
| Colorectal cancer | In vivo and vitro | [35] | |||
| Breast cancer | Bioinformatics analysis | [40] | |||
| Liver cancer | Bioinformatics analysis | [51] | |||
| Melanoma | In vivo | [62] | |||
| CXCL13 | B-lymphocyte chemoattractant(BLC)/B-cell attracting chemokine 1 (BCA-1) | CXCR3/5 | Lung cancer | In vitro | [26] |
| Gastric cancer | In vivo | [27] | |||
| Colorectal cancer | In vivo | [30] | |||
| Breast cancer | In vivo | [38] | |||
| CXCL14 | Breast and kidney-expressed chemokine (BRAK) | CXCR4 | Gastric cancer | In vivo | [27] |
| Breast cancer | Bioinformatics analysis | [40] | |||
| Liver cancer | Bioinformatics analysis | [51] | |||
| Prostate cancer | In vitro | [135] | |||
| Ovarian cancer | In vivo and vitro | [58] | |||
| CXCL16 | Scavenger receptor that binds phosphatidylserine oxidized lipoprotein (SR-PSOX) | CXCR6 | Gastric cancer | In vivo and vitro | [131] |
| Colorectal cancer | In vivo and vitro | [136] | |||
| Liver cancer | In vivo and vitro | [137] | |||
| Breast cancer | In vitro | [138] | |||
| CXCL17 | Dendritic cell and monocyte-like protein (DMC)/VEGF co-regulated chemokine 1 (VCC-1) | CXCR8 | Gastric cancer | Bioinformatics analysis | [28] |
| Colorectal cancer | In vivo | [139] | |||
| Breast cancer | In vivo and vitro | [39] |