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. 2023 Jul 1;9(1):14. doi: 10.1038/s41514-023-00111-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — iDCs were cultured for 3 days under static or RPM conditions in loose and dense matrices. a Heatmap of total DEGs in samples after RNA sequencing analysis. Volcano plots depicting up- and downregulated DEGs of iDCs cultured on the RPM compared to static in b loose and c dense matrices. d Venn diagram of the number of DEGs of iDCs cultured on the RPM compared to static in either loose or dense matrices. Top 15 enriched biological process pathways under RPM conditions in e loose and f dense matrices.