Fig. 2.

EC and PT scores of patients with early and more advanced disease stages at baseline significantly decline at a similar rate over time.

(A) The EC score was significantly predicted by disease duration (estimate=−0.42, 95%CI=[−0.98, 0.13], p=0.061), but the interaction disease duration by disease severity at baseline (very mild/mild versus moderate/severe) was not significant. This shows that patients who are in both early and more advanced disease stages show similar rates of decline on the EC subscale. (B) Disease duration significantly predicted the PT score in the main effect model (estimate=−0.21, 95%CI=[−0.57, 0.15], p=0.074). However, the interaction between disease duration and disease severity at baseline (very mild/mild versus moderate/advanced) did not reach statistical significance, demonstrating that rate of decline on the PT subscale is independent from disease severity at baseline. Age at symptom onset and sex were added to each model as covariates of no interest. CDR^® plus NACC FTLD=CDR^® Dementia Staging Instrument plus Behavior and Language domains from the NACC FTLD Module.