Table 1:

Demographic and clinical characteristics of patient sample.

	Asymptomatic pathogenic variant−	Asymptomatic pathogenic variant+	bvFTD pathogenic variant−	bvFTD pathogenic variant+	Behavioral MCI pathogenic variant+	p-value
n	163	114	219	88	10	--
Age at first evaluation	47.9 (13.6)	43.5 (14.5)	62.7 (8.7)	58.4 (8.5)	53.8 (12.5)	<0.0001
Pathogenic variant, C9orf72, GRN, MAPT	---	46, 30, 38	---	45, 13, 30	4, 3, 3	---
Sex, M/F	59/103	50/63	138/80	44/43	6/4	<0.0001
Education	15.5 (2.5)	15.6 (2.6)	15.7 (2.9)	15.3 (2.8)	14.8 (2.0)	=0.512
Global CDR® plus NACC FTLD	0	0	1.6 (0.7)	1.6 (0.7)	0.6 (0.2)	<0.001

bvFTD=behavioral variant frontotemporal dementia; MCI=Mild Cognitive Impairment; C9orf72=Chromosome 9 open reading frame 72; GRN=Progranulin; MAPT=Microtubule-associated protein tau; M=Male, F=Female; CDR^® plus NACC FTLD= CDR^® Dementia Staging Instrument plus Behavior and Language domains from the NACC FTLD Module

Longitudinal behavior subsample: Number of patients with 2 timepoints: 34; Number of patients with 3 timepoints: 13; Number of patients with 4+ timepoints: 4; Number of healthy controls with 2 timepoints: 55; Number of healthy controls with 3 timepoints: 30; Number of healthy controls with 4+ timepoints: 45.