Table 3.
Characteristics of the patients with at least 6 months’ survival time after AE-ILD
| Parameter | Total (n = 65) | IPF (n = 33) | Other ILD (n = 32) | P-value |
|---|---|---|---|---|
| Male gender | 41 (63.1) | 22 (66.7) | 19 (59.4) | 0.612 |
| Age at hospitalisation (years) | 72.5 (9.7) | 73.8 (8.7) | 71.2 (10.6) | 0.289 |
| Age at follow-up visit | 73.2 (9.6) | 74.2 (8.8) | 72.2 (10.4) | 0.409 |
| ILD diagnosed first time during AE-ILD | 26 (30.0) | 11 (33.3) | 15 (46.9) | 0.265 |
| Time from hospital discharge to follow-up visit (months)a | 5.8 (2.8 − 12.2) | 5.9 (3.6 − 11.1) | 5.6 (2.8 − 12.2) | 0.360 |
| Body mass index measured during hospital treatmentb | 28.1 (4.1) | 30.1 (5.7) | 26.3 (3.5) | 0.010 |
| Body mass index at follow-upc | 29.1 (5.5) | 30.2 (6.1) | 28.1 (4.7) | 0.228 |
| Oxygen requirement during hospital treatment | ||||
| None | 2 (3.1) | 1 (3.0) | 1 (3.1) | 0.542 |
| Nasal cannula | 44 (67.7) | 24 (72.7) | 20 (62.5) | |
| Oxygen mask | 2 (3.1) | 1 (3.0) | 1 (3.1) | |
| HFNO | 4 (6.2) | 2 (6.1) | 2 (6.3) | |
| CPAP | 3 (4.6) | 0 | 3 (9.4) | |
| Non-invasive ventilation | 6 (9.2) | 2 (6.1) | 4 (12.5) | |
| Intubation | 4 (6.2) | 3 (9.1) | 1 (3.1) | |
| Intubation or non-invasive mechanical ventilation support during hospital treatmentd | 13 (20.0) | 5 (15.2) | 8 (25.0) | 0.321 |
| ≥ 1 non-elective respiratory re-hospitalisation before the follow-up visita | 28 (44.4) | 18 (56.3) | 10 (32.3) | 0.055 |
| Non-elective respiratory re-hospitalisationsa | 0 (0 − 4) | 0 (0 − 3) | 0 (0 − 3) | 0.246 |
| Time from hospital discharge to respiratory re-hospitalisation (days)a | 71 (5 − 260) | 72 (5 − 211) | 47 (5 − 260) | 0.649 |
| Home oxygen therapy at follow-upa | 35 (55.6) | 21 (65.6) | 14 (45.2) | 0.102 |
| Supplementary oxygen rate (l per min) | 2 (1 − 8) | 2 (1 − 6) | 3 (1 − 8) | 0.200 |
| Pulmonary function test results at follow-up | ||||
| VC% of predictede | 61.9 (18.1) | 62.2 (15.4) | 61.7 (20.7) | 0.938 |
| FVC% of predictedf | 65.0 (17.7) | 66.7 (16.3) | 63.5 (19.2) | 0.551 |
| FEV1% of predictedf | 68.6 (17.5) | 70.7 (16.3) | 66.6 (18.8) | 0.438 |
| FEV1/FVCg | 83.5 (5.9) | 83.8 (5.9) | 83.2 (6.0) | 0.708 |
| DLCO% of predictedh | 42.5 (15.3) | 39.5 (14.6) | 45.2 (15.8) | 0.259 |
Data are expressed as number of cases (%), mean (standard deviation), or median (minimum − maximum)
Abbreviations: AE-ILD Acute exacerbation of interstitial lung disease, CPAP Continuous positive airway pressure, DLCO Diffusion capacity for carbon monoxide, FEV1 Forced expiratory volume in the first second; FVC, forced vital capacity; HFNO, high-flow nasal oxygen; ILD, interstitial lung disease; IPF, idiopathic pulmonary fibrosis; NIV, non-invasive ventilation; VC, vital capacity
aThe detailed follow-up data of two survivors were missing, because 1 IPF and 1 other ILD patient were treated in a different hospital. However, survival data of these patients was available
bData of 10 IPF and 7 other ILD patients were missing
cData of 14 IPF and 11 other ILD patients were missing
dEither CPAP, non-invasive ventilation support or invasive mechanical ventilation
eData of 14 IPF and 12 other ILD patients were missing
fData of 12 IPF and 9 other ILD patients were missing
gData of 11 IPF and 9 other ILD patients were missing
hData of 15 IPF and 12 other ILD patients were missing