Table 2. Antitumor effect and signaling pathway of crocin in vivo.

Work way	Tissue type	Dosage	Signaling pathways	Selective toxicity	REF
Proliferation	Breast tumors	200 mg/kg/d	CyclinD1, P21	Not mentioned in the article	49
	Colonic adenocarcinomas	50, 100, 200 ppm	NF- κB, Nrf2	Yes	66
Metastasis	Melanoma	250, 500 µg/kg/d	MMP-2, MMP-9, VEGF	Not mentioned in the article	76
	Breast cancer	200 mg/kg/d	Wnt/ β-catenin	Not mentioned in the article	82
Nanoliposomes administration mode	Colon carcinoma	50, 100 mg/kg/d		Not mentioned in the article	86
Combination with cisplatin	Kunming mice	6.25, 12.5 mg/kg/d	P38, p53, caspase-3	Not mentioned in the article	96
Autophagy	Cardiac tissues	50 mg/kg/d	AMPK, AKT, mTOR	Not mentioned in the article	116