Table 1.

Inflammatory diseases and their NLRP3 activators and cytokines which is released by NLRP3 activation to specific diseases respectively

Disease	NLRP3 Activators	Cytokines	References
Asthma	Various pathogens, toxins, bacteria, RNA and Der f1	IL-1β, IL-18	Whelan et al., 2004; Mariathasan and Monack, 2007; Besnard et al., 2011; Tsai et al., 2018
Atopic Dermatitis	Staphylococcus aureus, S. aureus linked α-toxins	IL-1β, IL-18, IL-5, IL-31	Marples et al., 1973; Tomi et al., 2005; Arend et al., 2008; Munoz-Planillo et al., 2009; Boguniewicz and Leung, 2010; Niebuhr et al., 2014
Sepsis	ROS, mtDNA,TLR4 agonist and LPS	IL-1β, IL-18, IL-33	Martin et al., 2003; Bauernfeind et al., 2009; Willingham et al., 2009; Yin et al., 2011; Kamo et al., 2013; Luo et al., 2014