Fig. 10.

In vivo therapeutic effects of DOX/DTNPs. A Illustration of the procedures for the treatment of retinoblastoma. B In vivo bioluminescence images of the eyes in orthotopic WERI-Rb-1-GFP-luc tumor-bearing BALB/c nude mice on days 1, 7, 15, and 25. C Tumor growth curve presented by the intensity of bioluminescence of tumors after intravenous injection of various formulations. D Body weight changes of the mice in each group. Data were shown as means ± SD (n = 4). *p < 0.05. E H&E staining of the orthotopic retinoblastoma and retina tissue after different treatments. The scale bar is 200 µm. Attribution 4.0 International (CC BY 4.0). Copyright 2021, Wiley. Reproduced from [86] with permission