FIGURE 2.

Regulatory signatures of cytokine signaling in acute inflammation. (A) Ingenuity Pathway Analysis of biological processes involved in SES–induced inflammation. (B) GSEA shows the impact of Th1 cells on Jak–STAT cytokine signaling and IFN-regulated outcomes. A summary of the complete GSEA analysis is provided in Supplemental Fig. 1. (C) Ingenuity Pathway Analysis of upstream regulators. Predicted p value (Fisher’s exact test) identifies gene signatures characteristic of specific transcription factors linked to TLR (NF-κB, Rel-A are shown), IFN (yellow; IRF family members are shown), and Jak–STAT cytokine signaling (red; STAT1 and STAT3 are displayed).