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. 2023 Jun 19;17:1188672. doi: 10.3389/fncel.2023.1188672

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Copyright © 2023 Charlton, Prowse, McFee, Heiratifar, Fortin, Paquette and Hayley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lipopolysaccharide and BDNF influenced LDH release in primary microglia. Release of the cytoplasmic enzyme, lactate dehydrogenase (LDH), into the microglia media indicated that LPS (100 ng/ml) treatment induced some membrane leakiness and potential cytotoxicity. In contrast, when the LPS-treated cells were also exposed to BDNF this effect was not only reversed, but LDH release was diminished compared to all vehicle treated cells. n = 3 separate cultures/group. Vehicle treatment was PBS. *p < 0.05, relative to vehicle only treatment, ^φp < 0.01, relative to all other groups.