Table 4.
Baseline characteristics of the application data sets with diseased brain samples and their corresponding normal controls.
| Condition | N | Mean age (sd) | n Male (%) | Brain region | GEO accession |
|---|---|---|---|---|---|
| Alzheimer’s disease | 16 | 93.31 (19.58) | 4 (25.0) | Basal ganglia | GSE72778 (44) |
| Healthy control | 14 | 54.79 (16.84) | 11 (78.6) | Basal ganglia | GSE72778 |
| Autism | 22 | 36.27 (7.05)* | 22 (100.0) | Cortex | GSE53924 (52) |
| Healthy control | 23 | 38.01 (10.82)* | 23 (100.0) | Cortex | GSE53924 |
| Huntington’s disease | 197 | 56.14 (14.85) | 124 (62.9) | Basal ganglia, Cortex | GSE72778 |
| Healthy control | 119 | 56.13 (18.16) | 90 (75.6) | Basal ganglia, Cortex | GSE72778 |
| Epilepsy | 19 | 39.43 (7.67)* | 10 (52.6) | Cortex, Hippocampus | GSE168916 (53) |
| Healthy control | 14 | 63.04 (10.76)* | 10 (71.4) | Cortex, Hippocampus | GSE168916 |
| Schizophrenia | 20 | 62.05 (15.87) | 11 (55.0) | Cortex | GSE61431 (47) |
| Healthy control | 23 | 62.04 (18.74) | 17 (73.9) | Cortex | GSE61431 |
| Total | 467 |
*
Horvath methylation age was inferred using the ENMIX due to the lack of age information.