TABLE 5.

Treatment‐related adverse events.

Toxicity	Any grade	Grade 3	Grade 4	Grade ≥3
Hematologic
Leukocytopenia	15 (51.7)	6 (20.7)	2 (6.9)	8 (27.6)
Neutropenia	16 (55.2)	4 (13.8)	5 (17.2)	9 (31.0)
Thrombocytopenia	2 (6.9)	0	0	0
Anemia	16 (55.2)	0	0	0
Febrile neutropenia	0	0	0	0
Nonhematologic
AST increase	4 (13.8)	1 (3.4)	0	1 (3.4)
ALT increase	4 (13.8)	1 (3.4)	0	1 (3.4)
Nausea	4 (13.8)	0	0	0
Anorexia	6 (20.7)	0	0	0
Joint pain	2 (6.9)	0	0	0
Myalgia	0	0	0	0
Peripheral sensory neuropathy	12 (41.4)	2 (6.9)	0	2 (6.9)
Alopecia	17 (58.6)	0	0	0
Rash	2 (6.9)	0	0	0
Interstitial lung disease	3 (10.3)	1 (3.4)	0	1 (3.4)
Fatigue	1 (3.4)	0	0	0
Paronychia	1 (3.4)	0	0	0
Creatinine increase	1 (3.4)	0	0	0
Tears	1 (3.4)	0	0	0
Eye disorders (macular edema)	1 (3.4)	0	0	0
Diarrhea	1 (3.4)	0	0	0
Bronchitis	1 (3.4)	0	0	0

Note: All values are given as n (%).

Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase.