TABLE 2.
Univariate and multivariate analysis in prognosis of colorectal cancer patients.
| Characteristics | Univariate analysis HR (95% CI) | p value | Multivariate analysis HR (95% CI) | p value |
|---|---|---|---|---|
| Sex | 0.42 | — | — | |
| Male | 1.14 (0.83–1.55) | |||
| Female | ||||
| Age (years) | <0.01 | <0.01 | ||
| ≤65 | ||||
| >65 | 1.93 (1.44–2.59) | 1.71 (1.19–2.45) | ||
| BMI a | 0.22 | — | — | |
| <18.5 kg*m2‐1 | ||||
| 18.5–23.5*kg m2‐1 | 0.66 (0.36–1.20) | |||
| >23.5 kg*m2‐1 | 0.09 (0.32–1.71) | |||
| History of preoperative radiochemotheray | 0.48 | — | — | |
| No | ||||
| Yes | 1.34 (0.59–3.02) | |||
| HTN | 0.3 | — | — | |
| No | ||||
| Yes | 1.18 (0.87–1.61) | |||
| DM | 0.25 | — | — | |
| No | ||||
| Yes | 1.26 (0.85–1.88) | |||
| CHD | 0.63 | — | — | |
| No | ||||
| Yes | 0.86 (0.47–1.59) | |||
| COPD | 0.55 | — | — | |
| No | ||||
| Yes | 1.24 (0.61–2.52) | |||
| History of stroke | 0.03 | 0.89 | ||
| No | ||||
| Yes | 1.57 (1.03–2.38) | 0.97 (0.62–1.51) | ||
| Anemia | 0.39 | |||
| No | ||||
| Yes | 1.18 (0.81–1.70) | |||
| Albumin | 0.019 | 0.47 | ||
| <40 g*L‐1 | ||||
| ≥40 g*L‐1 | 0.69 (0.51–0.94) | 1.14 (0.80–1.61) | ||
| WBC (109*L‐1) | 1.05 (0.98–1.12) | 0.17 | — | — |
| Neu (109*L‐1) | 1.09 (1.02–1.17) | 0.02 | 1.01 (0.94–1.08) | 0.81 |
| PLT (109*L‐1) | 1 (1–1) | 0.71 | — | — |
| AST | 0.02 | 0.06 | ||
| Normal | ||||
| Abnormal | 1.89 (1.13–3.15) | 1.73 (0.97–3.06) | ||
| DBIL b | 0.27 | — | — | |
| 0–6 μmol*L‐1 | ||||
| >6 μmol*L‐1 | 1.31 (0.83–2.08) | |||
| ASA | <0.01 | <0.01 | ||
| 2 | ||||
| 3 | 1.75 (1.22–2.52) | 0.03 | 1.10 (0.74–1.65) | |
| 4 | 165.33 (33.1–825.83) | <0.01 | 39.55 (7.24–216.15) | |
| The type of operation | <0.01 | 0.37 | ||
| Laparoscopic surgery | ||||
| Open surgery | 2.23 (1.56–3.19) | 1.21 (0.80–1.84) | ||
| TNM stage | <0.01 | <0.01 | ||
| Stage 0–I | ||||
| Stage II | 3.37 (1.60–7.10) | 0.01 | 2.75 (1.27–5.93) | |
| Stage III | 8.03 (3.89–16.54) | <0.01 | 5.96 (2.81–12.62) | |
| Stage IV | 33.81 (15.24–75) | <0.01 | 14.10 (6.04–32.90) | |
| Histological type | <0.01 | <0.01 | ||
| Adenocarcinoma | ||||
| Mucinous | 1.07 (0.548–2.103) | 0.84 | 1.74 (0.76–3.99) | |
| Others | 5.66 (3.07–10.45) | <0.01 | 5.54 (2.40–12.78) | |
| Histologic grade | 0.01 | 0.16 | ||
| Well | ||||
| Moderate | 3.01 (1.23–7.37) | 0.02 | 1.73 (0.69–4.31) | |
| Poorly | 4.37 (1.73–11.01) | <0.01 | 1.96 (0.76–5.05) | |
| Unknown | 3.86 (1.36–10.96) | 0.01 | 0.8 (0.23–2.79) | |
| Location | 0.62 | — | — | |
| Colon | ||||
| Rectum | 0.86 (0.64–1.16) | |||
| Tumor size | 0.89 | — | — | |
| ≤5 cm | ||||
| >5 cm | 1.02 (0.74–1.42) | |||
| CEA | <0.01 | <0.01 | ||
| ≤5 ng*mL‐1 | ||||
| >5 ng*mL‐1 | 2.78 (1.99–3.89) | <0.01 | 1.70 (1.18–2.43) | |
| Unknown | 3.32 (2.14–5.16) | <0.01 | 1.42 (0.26–7.76) | |
| CA19‐9 | <0.01 | 0.01 | ||
| ≤37 U*mL‐1 | ||||
| >37 U*mL‐1 | 2.84 (1.94–4.15) | <0.01 | 1.94 (1.29–2.91) | |
| Unknown | 2.32 (1.56–3.44) | <0.01 | 1.46 (0.27–7.86) | |
| Postoperative adjuvant chemotherapy | <0.01 | 0.02 | ||
| No | ||||
| Yes | 0.67 (0.49–0.9) | 0.65 (0.45–0.93) | ||
| RDW | <0.01 | 0.02 | ||
| <13.5% | ||||
| ≥13.5% | 1.56 (1.15–2.11) | 1.52 (1.11–2.08) | ||
| ΔRDW | <0.01 | <0.01 | ||
| <0.9% | ||||
| ≥0.9% | 2.24 (1.66–3.02) | 1.65 (1.19–2.28) |
a
46 patients were missing.
b
24 patients were missing.