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. 2023 May 29;27(13):1836–1858. doi: 10.1111/jcmm.17782

FIGURE 4.

FIGURE 4

Hypoxic preconditioned bone marrow‐derived mesenchymal stem cells (HP‐BMSCs) attenuated neurological damage following cardiac arrest and cardiopulmonary resuscitation in rats. (A) HP‐BMSCs ameliorated the cerebral cortex pathological injury in rats with global cerebral ischaemia–reperfusion. Black arrows in representative images indicate damaged cells and mainly manifested as vacuolated cytoplasm with deeply stained nuclei. Scale bar = 100 μm (n = 5–6). (B) Neurological deficit scores showed HP‐BMSCs improved neurologic function recovery after resuscitation (n = 5–6). (C, D) The serum S100B and neuron‐specific enolase (NSE) levels were reduced with intracerebroventricular HP‐BMSCs injection (n = 5–6). All data are presented as means ± SD. *p < 0.05 vs. the sham group. # p < 0.05 vs. the CPR + PBS group. & p < 0.05 vs. the CPR + normal‐cultured BMSCs (N‐BMSCs) group.