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. 2023 May 29;27(13):1836–1858. doi: 10.1111/jcmm.17782

FIGURE 5.

FIGURE 5

Hypoxic preconditioned bone marrow‐derived mesenchymal stem cells (HP‐BMSCs) ameliorated neuronal pyroptosis in cerebral cortex at various time points following resuscitation. (A, B) The expression of NLRP3 (red) and cleaved‐caspase‐1 (red) in neurons (NeuN, green) was examined by immunofluorescence double labelling and DAPI (blue) staining of the cell nuclei. Scale bar = 100 μm (n = 5–6). (C, D) Statistical comparison of NLRP3+ NeuN+/NeuN+ or cleaved‐caspase‐1+ NeuN+/NeuN+ levels among groups. The percentage of NLRP3+ NeuN+ cells within NeuN+ cells, and cleaved‐caspase‐1+ NeuN+/NeuN+ was similar. All data are expressed as the means ± SD. *p < 0.05 vs. the sham group. # p < 0.05 vs. the CPR + PBS group. & p < 0.05 vs. the normal‐cultured BMSCs (N‐BMSCs) group.