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. 2023 Jun 19;10:1208275. doi: 10.3389/fvets.2023.1208275

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Copyright © 2023 Zajac, Trujillo, Yao, Kumar, Sangewar, Lokhandwala, Sang, Mallen, McCall, Burton, Kumar, Heitmann, Burnum, Waghela, Almes, Richt, Kim and Mwangi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Survival and viremia post-challenge. Viremia (CN/mL) in (A) blood and (B) nasal swabs from contact non-immunized spreaders on days 0, 5, and 7; and blood from the treatment groups on days 0, 5, 7, 11, and 14 which includes the day of euthanasia for the animals that developed severe clinical disease. The mean viremia was significantly different between the contact spreaders and Montanide ISA-201™ (*p = 0.417) and BioMize^® (**p = 0.0439) treatment groups, any groups not denoted with an asterisk were not statistically significant and the survivor is not represented here. (C) Pigs were monitored and euthanized based on the severity of the disease. All the non-immunized contact spreaders (CS) are shown in red with dashed lines. Average survival is indicated in parenthesis for each group.