Fig. 5.

Base-pair resolved SHAP values for the $16\times 23$ (left panel, see Fig. 4) and $6\times 23$ (right panel, see Figure S7) CNN classification models. SHAP values have been obtained on the held out studies [31], [32], [33] from the crisprSQL dataset. Note that high values of the NuPoP Affinity feature (red dots), i.e. highly positioned nucleosomes, always influence the model towards reduced cleavage activity (negative SHAP value). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)