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. 2022 Dec 15;108(7):1886–1899. doi: 10.3324/haematol.2022.281444

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Figure 3. — CCRL2 knockdown increases the clonogenicity inhibition and apoptotic effects of azacitidine. (A) CCRL2 knockdown (KD) by two different lentiviruses (sh1 and sh2) decreased the azacitidine half maximal inhibitory concentration (IC₅₀) for the clonogenicity of MDS92 cells (P<0.001 for both sh1 and sh2). (B) CCRL2 KD by two different lentiviruses (sh1 and sh2) decreased the azacitidine IC₅₀ for the clonogenicity of MDS-L cells (P<0.001 for both sh1 and sh2). (C) CCRL2 KD by two different lentiviruses (sh1 and sh2) decreased the azacitidine IC₅₀ for the clonogenicity of TF-1 cells (P<0.001 for both sh1 and sh2). (D) CCRL2 KD in MDS92 cells increased the percentage of early apoptotic and necrotic cells under treatment with 0.5 mM (P<0.001 with sh1 and P=0.005 with sh2) and 1 mM (P<0.001 with sh1 and P=0.007 with sh2) of azacitidine (n=3). (E) CCRL2 KD in MDS-L cells increased the percentage of early apoptotic and necrotic cells under treatment with 0.5 mM (P=0.028 with sh1 and P=0.003 with sh2) and 1 mM (P=0.003 with sh1 and P=0.035 with sh2) of azacitidine (n=3).