Figure 7.

CCRL2 expression in CD34⁺ cells is negatively correlated with response to DNMT inhibitors. (A) Genomic landscape of patients with myelodysplastic syndrome (MDS) and MDS/myeloproliferative neoplasms (MPN) included in the analysis sorted by CCRL2 levels with gender, disease subtype (MDS and MDS/MPN) and specific somatic mutations being indicated. MDS/MPN patients had higher levels of CCRL2 (P=0.033) and men had relatively higher levels compared to women (P=0.047). Patients who achieved complete or partial remission (CR or PR) are presented in blue, patients with stable disease (SD) are presented in orange and patients with progressive disease (PD) are presented in red. (B) Patients with CR/PR had lower CCRL2 levels in their CD34⁺ cells compared to patients with SD (P=0.029) or PD (P=0.002). (C) Kaplan-Meier analysis showed that CCRL2 protein levels above the median were associated with worse overall survival since diagnosis (P=0.039) compared to CCRL2 protein levels below the median.