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Integrin conformations. (A) Integrin in the resting state, with a folded ectodomain and low affinity for its ligands. (B) Integrin in the intermediate state with an extended ectodomain and a closed globular head. It has an intermediate affinity for its ligands. (C) Integrin in the high affinity state for its ligands, with an extended ectodomain and opened globular head exposing the ligand binding site.
