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. 2022 Sep 29;108(7):1861–1872. doi: 10.3324/haematol.2022.281505

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Figure 1. — Detection of β2-GPI on thrombi by immunofluorescence analysis. Clot sections were double stained with rabbit antibody to β2 glycoprotein 1 (β2-GPI) and either antibody to fibrin or to CD9, to investigate the localization of β2-GPI on fibrin, platelets and leukocytes. DAPI was used to stain cell nuclei. The thrombi were obtained from 2 different sources: (A) 3 patients undergoing surgical thrombectomy; (B) in vitro blood clots generated under static (platelet-poor) or flow (platelet-rich) conditions (see Methods for additional details). Representative images of thrombus section from 1 patient showing absence of co-staining of β2-GPI and fibrin. Arrows highlight the co-localization of β2-GPI with CD9-positive structures and arrowheads show the co-localization of β2-GPI with DAPI-positive nucleated cells.