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. 2022 Sep 29;108(7):1861–1872. doi: 10.3324/haematol.2022.281505

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Figure 6. — Localization of targeted and untargeted nonobubbles (tNB and NB) (without recombinant tissue plasminogen activator [rtPA]) on vascular thrombi induced by ferric chloride and effect of rtPA-NB, rtPA-tNB and soluble rtPA on vascular thrombotic occlusion. (A) Intravascular thrombi are visualized in red by in vivo staining with rhodamine 6G and in green by coumarin 6-loaded targeted nanobubbles (tNB). The images were collected 30 minutes after injection of NB. Note the absence of thrombus green staining in rats that received untargeted NB. (B) Time course of vascular occlusion after treatment with rtPA-coated tNB or untargeted NB (0,2 mg/g body weight) or soluble recombinant tissue plasminogen activator (rtPA) (2 pg/g body weight), as assessed by intravascular microscopy analysis. A significant reduction in the number of occluded vessels was seen in rats treated with targeted NB (rtPA-tNB) but not in those treated with untargeted NB or soluble rtPA. The results are presented as mean ± standard deviation of experiments conducted in 3 rats. *P<0.05, **P< 0.005 using one-way ANOVA followed by Student-New-man-Keuls test.