Table 1.

Oncogenic Substrates of LIMK2: LIMK2 directly phosphorylates TWIST1, SPOP, NKX3.1 and PTEN at multiple sites.

Substrate	Role	Cancer	Phosphorylation Sites	Consequence of phosphorylation	Consequence on LIMK2
TWIST1	Oncogene	CRPC	S45, S78, S95, S199	Protein stabilized	LIMK2 Stabi ized
SPOP	Tumor Suppressor	CRPC	S59, S171, S226	Protein degraded	LIMK2 Degraded
NKX3.1	Tumor Suppressor	CRPC	S185	Protein degraded	LIMK2 Degraded
PTEN	Tumor Suppressor	CRPC	S207, S226, S360, S361, S362	Protein degraded and activity inhibited	LIMK2 Degraded