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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: Cancer Lett. 2023 May 2;565:216207. doi: 10.1016/j.canlet.2023.216207

Table 2:

LIMK2 is known to be associated with many human diseases. G3BP1: G3BP Stress Granule Assembly Factor 1; ESM1: Endothelial Cell Specific Molecule 1.

LIMK2 Disease Consequences Downstream Molecular Mechanisms
Overexpression CRPC Tumorigenesis, Drug Resistance, Poor prognosis Phosphorylation of SPOP, PTEN, NKX3.1, TWIST1
Overexpression Breast cancer including TNBC Tumorigenesis and Metastasis Positively regulates AURKA and SRPK1
Overexpression LUSC Negatively correlates with Immune cell Infiltration Not known
Overexpression SE Necrotic Degeneration upon SE by impairing DRP1-mediated mitochondrial fission
Missense mutation in LIMK2-1 Intellectual Disability (ID) Rare LIMK2 mutation associated with ID Not known
Overexpression due to 3ยด-UTR SNP Bladder Cancer Correlates with risks of high-grade and highstage bladder cancer Not known
Overexpression due to LINC00460 Colorectal Cancer Correlates with poor prognosis Not known
LIMK2b overexpression due to TUG1 Small Cell Lung Cancer Cell growth and chemoresistance Not known
Overexpression Melanoma Tumorigenesis and Metastasis Via G3BP1-ESM1 pathway