Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jul 3;23:613. doi: 10.1186/s12885-023-11095-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 3 — Genomic determinants associated with OS outcome in OCCC. Survival data were analyzed in relation to genomic aberrations detected by OncoScan. A Survival analysis showing that amplification of the oncogene MYC is associated with better survival. B Survival analysis showing a subgroup within MYC-amplified OCCCs with better prognosis that was defined by the concomitant loss of chromosome region 13q12-q13, which includes the BRCA2 gene (MB group). C Survival analysis for OCCCs that do not bear concomitant MYC amplification and 13q12-q13 loss (non-MB OCCCs). A subgroup of OCCCs with few CN aberrations shows better survival (FC group). The OCCCs not belonging to either the MB or FC groups that showed the worst survival were named the PS group. D Summary of CN alterations in MYC and 13q12-q13. (E) Graph showing the total CN aberrations of each OS group. The dashed line was set at 30 CN aberrations. Significant differences were analyzed by the Kruskal-Wallis test. F-H Frequency plots were generated for the (F) MB, (G) FC and (H) PS OS groups. Significantly altered genes and regions (green line) are indicated. I Flowchart for the definition of OS groups (created with BioRender.com). J Survival analysis for the OS groups. K Summary of the Figo stage and platinum sensitivity of the samples within each OS group