Figure 5.

Stress altered circadian-regulated, GR-regulated, and IBS-related chromatin 3D structures

BL-Hi-C was performed with colon IECs isolated from two control (CT) and two water avoidance stressed (WAS) BALB/c mice; data from each group were combined for visualization; each RNA track represents the combined RNA-seq data from three mice; GR-CUT&Tag tracks are also shown. E-boxes (CACGTG) and differential GR binding are marked.

(A) Circadian gene Dbp chromatin.

(B) Circadian chromatin hub Pard3.

(C) The NR1D1 target circadian gene Npas2.

(D) GR target gene Fkbp5 stripe-like structure.

(E) IBS-related Cdh3 (P-cadherin)-Cdh1 (E-cadherin) chromatin.