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. 2023 Jun 20;26(7):107187. doi: 10.1016/j.isci.2023.107187

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© 2023 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Bifunctional transcription factors are involved in mediating the transcriptome change in trNK induced by the additional IL-21 stimulation

(A) Workflow of the ATAC-Seq analysis of ex vivo stimulated liver trNK.

(B) Schematics showing screening of concordant ChARs for the upregulated or downregulated genes by additional IL-21 stimulation in trNK, and their related genes.

(C) Heatmap profiling of concordant ChARs for the upregulated (left) or downregulated (right) genes by additional IL-21 stimulation in trNK.

(D) Pie charts showing proportions of the concordant ChAR-related genes in upregulated (top) or downregulated (bottom) genes by additional IL-21 stimulation in trNK.

(E) Go analysis of the concordant ChAR-related genes upregulated (top) or downregulated (bottom) by additional IL-21 stimulation in trNK.

(F) Scatterplots of potential transcription factors for the concordant ChAR-related genes upregulated (left) or downregulated (right) by additional IL-21 stimulation in trNK, showing both sufficient expression and substantial regulatory roles.

(G) Profiling of each potential transcription factor in (F), showing the percentage of their potentially regulated genes within the upregulated or downregulated genes by additional IL-21 stimulation in trNK in trNK (left) and their expression in trNK under the indicated stimulatory conditions (right).