Table 3.
Multivariate analysis of transplant outcomes by donor type
| Outcome by donor type | Evaluable | Events | HR (95% CI) | P-value |
|---|---|---|---|---|
| Neutrophil engraftment | ||||
| Haploidentical | 1753 | 1681 | 0.82 (0.68 – 0.97) | 0.025 |
| Matched unrelated | 292 | 288 | 1.00 | |
| Platelet recovery | ||||
| Haploidentical | 1645 | 1423 | 0.69 (0.59 – 0.80) | <0.001 |
| Matched unrelated | 258 | 243 | 1.00 | |
| Acute GVHD II-IV | ||||
| Haploidentical | 1690 | 590 | 1.65 (1.28 – 2.14) | <0.001 |
| Matched unrelated | 279 | 71 | 1.00 | |
| Acute GVHD III-IV | ||||
| Haploidentical | 1707 | 179 | 2.04 (1.28 – 3.25) | 0.003 |
| Matched unrelated | 286 | 17 | 1.00 | |
| Chronic GVHD | ||||
| Haploidentical | 1721 | 464 | 1.79 (1.30 – 2.48) | <0.001 |
| Matched unrelated | 277 | 58 | 1.00 | |
| Relapse | ||||
| Haploidentical | 1720 | 465 | 1.04 (0.78 – 1.38) | 0.805 |
| Matched unrelated | 292 | 63 | 1.00 | |
| Non-relapse mortality | ||||
| Haploidentical | 1728 | 367 | 1.93 (1.21 – 3.07) | 0.006 |
| Matched unrelated | 293 | 41 | 1.00 | |
| Progression or death | ||||
| Haploidentical | 1728 | 838 | 1.39 (1.10 – 1.79) | 0.008 |
| Matched unrelated | 294 | 104 | 1.00 | |
| Overall mortality | ||||
| Haploidentical | 1830 | 684 | 1.69 (1.30–2.27) | <0.001 |
| Matched unrelated | 310 | 79 | 1.00 |
Abbreviations: GVHD, graft-versus-host-disease; CI, confidence interval
Neutrophil engraftment: adjusted by patient age, HCT CI, sex match; stratified by population resources, GVHD prophylaxis, graft type and conditioning regimen.
Platelet recovery: adjusted by Patient age, HCT CI, CMV match, disease stage, time from diagnosis to transplant; stratified by population resources, GVHD prophylaxis, graft type and conditioning regimen.
Acute GVHD II-IV: adjusted by donor age, HCT CI; stratified by population resources, GVHD prophylaxis, graft type and conditioning regimen. Acute GVHD III-IV: adjusted by previous auto HCT; stratified by population resources, GVHD prophylaxis, graft type and conditioning regimen. cGVHD: adjusted by previous auto HCT; stratified by population resources, GVHD prophylaxis, graft type and conditioning regimen.
Relapse: adjusted by year of transplant; stratified by disease stage, time from diagnosis to transplant, population resources, GVHD prophylaxis, graft type and conditioning regimen.
Non-relapse mortality: adjusted by patient age, disease stage, donor age, CMV match, Karnofsky score; stratified by population resources, GVHD prophylaxis, graft type and conditioning regimen.
Progression or death: Inverse of progression-free survival; adjusted by disease stage, CMV match; stratified by disease type, donor age, population resources, GVHD prophylaxis, graft type and conditioning regimen.
Overall mortality: inverse of overall survival; djusted by patient age, disease stage, HCT CI, CMV match, Karnofsky score; stratified by disease type, donor age, population resources, GVHD prophylaxis, graft type and conditioning regimen.