Table 1.
Demographic and vascular risk factors, and imaging characteristics for the healthy control group, CADASIL group and heterozygous HTRA1 mutation-related CSVD group
| HC | CADASIL | HTRA1 | P-value | |
|---|---|---|---|---|
| Number | 24 | 24 | 9 | |
| Age, years | 42.88 ± 12.34 | 44.17 ± 14.14 | 42.78 ± 15.14 | 0.936 |
| Sex, male | 6/24 | 9/24 | 6/9 | 0.087 |
| Education | 9.00 (11.00) | 11.08 ± 4.60 | 12.00 (6.50) | 0.590 |
| Vascular risk factors | ||||
| TIA/stroke | 0/24 | 8/24 | 6/9 | <0.001a,b |
| Smoking | 2/24 | 4/20 | 6/9 | 0.002b,c |
| Alcohol consumption | 4/20 | 4/20 | 3/9 | 0.490 |
| Hypertension | 0/24 | 1/24 | 0/9 | 1.000 |
| Diabetes mellitus | 0/24 | 1/24 | 0/9 | 1.000 |
| Dyslipidaemia | 6/18 | 1/23 | 0/9 | 0.063 |
| Imaging characteristics | ||||
| WMH volume | 0.05 (0.19) | 17.46 ± 12.05 | 15.45 ± 14.58 | <0.001a,b |
| Normalized WMH volume ratio | 0.371 × 10−4 (0.00014) | 0.012 ± 0.009 | 0.010 ± 0.010 | <0.001a,b |
| Lacunar infarcts | 0/24 | 11/24 | 6/9 | <0.001a,b |
| Microbleeds | 0/24 | 12/24 | 6/9 | <0.001a,b |
| ePVS | 0/24 | 10/24 | 4/9 | <0.001a,b |
| CSVD score | – | 2.00 (1.75) | 3.50 (3.75) | – |
Data are mean ± SD or median (IQR). HC = healthy controls.
For the comparison between the CADASIL and HC (Bonferroni-corrected P < 0.05).
For the comparison between the HTRA1 and HC (Bonferroni-corrected P < 0.05).
For the comparison between the CADASIL and HTRA1 (Bonferroni-corrected P < 0.05).