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. 2022 Dec 20;146(7):2913–2927. doi: 10.1093/brain/awac486

Figure 6.

Figure 6

The risk of stroke between the NOTCH3cys EGFr risk categories in the CADASIL and population genotype–phenotype data set. A survival curve (A) and interval plot (B), both corrected for cardiovascular risk factors and sex, showing that MR-EGFr and HR-EGFr patients in the CADASIL genotype–phenotype data set had a significant earlier onset of stroke than individuals from the same EGFr risk category in the population genotype–phenotype data set [MR-EGFr: median 72 versus >78 years (P = 8.1 × 10−6); HR-EGFr: median 57 versus 74 years (P = 3.5 × 10−5)]. The risk of stroke of HR-EGFr individuals in the population data set and MR-EGFr patients from the CADASIL data set was similar (P = 0.54).