Table 1.
Subject demographics and clinical information
| Full cohort (n = 81) | SPES subcohort (n = 23) | Diffusion subcohort (n = 26) | |
|---|---|---|---|
| Sex, female (n, %) | 46 (56.8%) | 16 (69.6%) | 20 (76.9%) |
| Age (years, mean ± SD) | 34.4 ± 12.1 | 36.7 ± 11.7 | 35.2 ± 11.5 |
| Epilepsy duration (years, mean ± SD) | 16.4 ± 11.9 | 15.1 ± 9.0 | 14.8 ± 10.6 |
| FBTC seizures, yes (n, %) | 58 (71.6%) | 18 (78.2%) | 17 (65.4%) |
| MTS, yes (n, %) | 15 (18.5%) | 3 (13.0%) | 6 (23.1%) |
| Clinically presumed epilepsy subtype (n, %) | |||
| Unilateral mTLE | 28 (34.6%) | 8 (34.8%) | 12 (46.2%) |
| Bilateral mTLE | 12 (14.8%) | 3 (13.0%) | 4 (15.4%) |
| Unilateral lateral TLE | 10 (12.3%) | 4 (17.4%) | 2 (7.7%) |
| Unilateral frontal lobe epilepsy | 11 (13.6%) | 2 (8.7%) | 1 (3.8%) |
| Unilateral parietal lobe epilepsy | 4 (4.9%) | 1 (4.3%) | 2 (7.7%) |
| Multiple presumed foci (not bilateral mTLE) | 16 (19.8%) | 5 (21.7%) | 5 (19.2%) |
| Surgery type (n, %) | |||
| Resective SAH | 14 (17.3%) | 3 (13.0%) | 8 (30.8%) |
| ATL | 11 (13.6%) | 3 (13.0%) | 3 (11.5%) |
| Other resection | 10 (12.3%) | 1 (4.3%) | 2 (7.7%) |
| Laser SAH | 4 (4.9%) | 0 (0%) | 0 (0%) |
| RNS | 24 (29.6%) | 10 (43.5%) | 11 (42.3%) |
| DBS | 1 (1.2%) | 0 (0%) | 0 (0%) |
| None | 17 (21.0%) | 6 (26.1%) | 2 (7.7%) |
| Follow-up durationa (months, mean ± SD) | 26.7 ± 17.6 | 12.8 ± 7.8 | 35.3 ± 19.0 |
| SEEG nodes implanted (n, mean ± SD) | 124.3 ± 31.4 | 133.5 ± 23.6 | 127.5 ± 23.9 |
| SEEG nodes in grey matter (n, mean ± SD) | 85.4 ± 26.7 | 93.3 ± 19.0 | 78.8 ± 23.9 |
| SEEG nodes stimulated (n, mean ± SD) | NA | 60.0 ± 10.7 | NA |
| SEEG node designations (n, mean ± SD) | |||
| SOZ | 11.2 ± 9.2 | 13.7 ± 11.2 | 12.2 ± 9.6 |
| PZ | 9.0 ± 10.3 | 7.6 ± 7.4 | 6.24 ± 6.9 |
| NIZ | 65.2 ± 23.4 | 72.0 ± 18.6 | 66.9 ± 21.6 |
ATL = anterior temporal lobectomy; DBS = deep brain stimulation of bilateral anterior thalamic nuclei; FBTC = focal to bilateral tonic-clonic seizures; mTLE = mesial temporal lobe epilepsy; MTS = mesial temporal sclerosis; RNS = responsive neurostimulation; SAH = selective amygdalohippocampectomy; TLE = temporal lobe epilepsy.
Only for resective surgeries.