Table 3. Performance of different cut-off points of Ki67 expression to determine the cCR according to the ROC curve analysis.

Ki67 cutoff	Sensitivity	Specificity	PPV	NPV
≥ 10% versus < 10%	95.35	20.31	44.57	86.67
≥ 14% versus < 14%	86.10	39.10	48.68	80.65
≥ 20% versus < 20%	76.74	43.75	47.83	73.68
≥ 30% versus < 30%	46.51	67.19	48.78	65.15

Abbreviations: CCR, clinical complete response; NPV, negative predictive value; PPV, positive predictive value; ROC, receiver operating characteristic.

Note: Data are presented as percentages.